Evidence & progress

Whether the mother developed pre-eclampsia, with or without severe features, during the trial.

Outcome 0 claims Evidence checked not recorded

One combined measure of serious problems in the pregnancy: pre-eclampsia with severe features, a medically needed early birth before 35 weeks, the placenta separating from the womb wall before the...

Outcome 0 claims Evidence checked not recorded

Dying for any reason during a study's follow-up.

Outcome 0 claims Evidence checked not recorded

Whether the baby died before birth or soon after birth. It is one of the four parts of the CHAP primary combined outcome, which counts fetal and newborn deaths together.

Outcome 0 claims Evidence checked not recorded

Whether the baby's temperature dropped too low at any point in hospital.

Outcome 0 claims Evidence checked not recorded

Whether the baby died in its first 28 days of life.

Outcome 0 claims Evidence checked not recorded

Whether the baby died in its first three days of life.

Outcome 0 claims Evidence checked not recorded

Whether the mother died and the cause recorded was bleeding. In WOMAN this was the main cause-specific death outcome.

Outcome 0 claims Evidence checked 2026-10-11

Whether the baby was born before 35 weeks of pregnancy because the mother or the baby was ill, and not because labor started on its own or the waters broke. It is one of the four parts of the CHAP...

Outcome 0 claims Evidence checked not recorded

Whether a baby who was born alive died in the first 28 days of life.

Outcome 0 claims Evidence checked not recorded

Whether the placenta came away from the wall of the womb before the birth and this led to the baby being delivered. CHAP also recorded other abruptions, but they did not count toward the primary...

Outcome 0 claims Evidence checked not recorded

Whether the mother developed pre-eclampsia with severe features, up to 2 weeks after the birth. It is one of the four parts of the CHAP primary combined outcome.

Outcome 0 claims Evidence checked not recorded

Whether a baby was born smaller than expected for the length of the pregnancy. CHAP used it to check that treating the mother did not slow the baby’s growth.

Outcome 0 claims Evidence checked not recorded

The main report of the WHO ACTION-I trial results, published in December 2020.

Publication Evidence checked not recorded

The main report of the CHAP trial, published in 2022, on treating mild chronic hypertension during pregnancy.

Publication Evidence checked not recorded

The main report of the WHO Immediate KMC Study results, published in May 2021.

Publication Evidence checked not recorded

The NICE guideline on diagnosing and managing high blood pressure in pregnancy, first published in June 2019 and last updated in April 2023.

Publication Evidence checked not recorded

WHO's 2022 guidance on caring for babies who are born early or small.

Publication Evidence checked not recorded

WHO's 2022 advice on giving steroid injections to pregnant women who are likely to give birth early.

Publication Evidence checked not recorded

The main report of the WOMAN trial of tranexamic acid for bleeding after birth, published in The Lancet in 2017.

Publication Evidence checked 2026-10-11

A large trial in the United States that asked whether women with mildly raised blood pressure before or early in pregnancy do better if they take blood pressure medicine to keep their pressure under...

Study Evidence checked not recorded

A trial in 29 hospitals in Bangladesh, India, Kenya, Nigeria and Pakistan. Pregnant women who were likely to give birth early received either a dexamethasone steroid injection or a dummy injection...

Study 1 claim Evidence checked not recorded

A trial in five hospitals in Africa and India that tested starting skin-to-skin care right after birth for small babies, compared with starting it after they stabilized.

Study 1 claim Evidence checked not recorded

A large trial that tested whether tranexamic acid, added to usual care, helps women who are bleeding heavily after giving birth. About 20 000 women in 193 hospitals in 21 countries took part. Neither...

Study Evidence checked 2026-10-11