Breastfeeding in the 21st century (Lancet 2016 Breastfeeding Series paper)

A review and meta-analysis in The Lancet in 2016 of what breastfeeding does for children and for mothers, with an estimate of how many deaths could be prevented if breastfeeding were near universal.

  • Publication
  • In this atlas

Overview

Technical summary

Lancet 2016 January 30 issue, a review and meta-analysis. The abstract reports protection against child infections and malocclusion, higher intelligence and probable reductions in overweight and diabetes; no association with allergic disorders such as asthma, blood pressure or cholesterol; increased tooth decay with longer breastfeeding; and for mothers protection against breast cancer and better birth spacing. Only the abstract was read; the effect sizes and the certainty of the evidence are not recorded. Funding and the series context were not read.

Bibliographic identity

Type
Review
Source
Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect
Edition
PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched.
Publisher
Lancet (London, England)
Published
2016-01-30

Claims and evidence

Context Children who were breastfed or breastfed longer, in the studies pooled by the 2016 Lancet review

Recipient
Child
Population
Children in the studies pooled by the review. The abstract compares low-income, middle-income and high-income countries and does not give a gestational age or birth weight limit.
Care setting
Not stated in the abstract (the review pools studies from many settings).
Geography
Low-income, middle-income and high-income countries (the abstract compares them without naming countries)
Life stage
Infants and children, with outcomes from infection in childhood to adult overweight and diabetes
Gestational age
Not reported
Postnatal age
Not reported
Follow-up
Not stated in the abstract.
Eligibility: 1 inclusion criterion; 1 exclusion criterion
Included
  • Children in the pooled studies
Excluded
  • Not stated in the source that was read
  • Effect Evidence synthesis Certainty not assessed

    The authors' meta-analyses indicate protection against child infections and malocclusion, increases in intelligence, and probable reductions in overweight and diabetes. They did not find associations with allergic disorders such as asthma, or with blood pressure or cholesterol, and they noted an increase in tooth decay with longer periods of breastfeeding.

    Applies to Child
    • Children in the studies pooled by the review. The abstract compares low-income, middle-income and high-income countries and does not give a gestational age or birth weight limit.
    • Not stated in the abstract (the review pools studies from many settings).
    • Low-income, middle-income and high-income countries (the abstract compares them without naming countries)
    • Infants and children, with outcomes from infection in childhood to adult overweight and diabetes
    • Gestational age Not reported
    • Postnatal age Not reported
    Follow-up Not stated in the abstract.
    Certainty method
    Not assessed
    Limitations
    Only the PubMed abstract of this review and meta-analysis was read; the full text was not. The abstract gives pooled conclusions without effect sizes. The abstract does not rate the certainty of the evidence, names no particular infection and gives no number for the size of any protection.
    Last checked
    2026-10-15
    Next evidence check due
    Not scheduled
    Sources and citations (3)
    1. Supports Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

      Publication · Lancet (London, England) · Edition PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched. · Published 2016-01-30 · DOI: 10.1016/S0140-6736(15)01024-7 · PMID: 26869575

      Locator
      Abstract, sentence 4
      How it applies
      PubMed abstract.
      Retrieved
      Source effective date
      Not reported
      Source state
      Current
      Snapshot hash
      880a968d1507804e2ba391e739f28569c97d4def79958233e4b1be5757a7ab92
      Reuse basis
      PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.
    2. Supports Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

      Publication · Lancet (London, England) · Edition PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched. · Published 2016-01-30 · DOI: 10.1016/S0140-6736(15)01024-7 · PMID: 26869575

      Locator
      Abstract, sentence 5, fragment 1 of 2
      How it applies
      PubMed abstract.
      Retrieved
      Source effective date
      Not reported
      Source state
      Current
      Snapshot hash
      880a968d1507804e2ba391e739f28569c97d4def79958233e4b1be5757a7ab92
      Reuse basis
      PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.
    3. Supports Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

      Publication · Lancet (London, England) · Edition PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched. · Published 2016-01-30 · DOI: 10.1016/S0140-6736(15)01024-7 · PMID: 26869575

      Locator
      Abstract, sentence 5, fragment 2 of 2
      How it applies
      PubMed abstract.
      Retrieved
      Source effective date
      Not reported
      Source state
      Current
      Snapshot hash
      880a968d1507804e2ba391e739f28569c97d4def79958233e4b1be5757a7ab92
      Reuse basis
      PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.

Context Modelled annual deaths in children younger than 5 years and in women if breastfeeding were near universal (2016 Lancet review)

Recipient
Mixed recipients
Population
Annual deaths in children younger than 5 years and annual deaths from breast cancer in women, estimated by the review's model for a scale-up of breastfeeding to a near universal level. The estimate is a projection, not an observed trial result.
Care setting
Not applicable (population-level estimate).
Geography
Not stated in the abstract for the estimate (the sentence refers to annual deaths without naming a region)
Life stage
Children younger than 5 years, and women
Gestational age
Not reported
Postnatal age
Not reported
Follow-up
Annual estimate; the horizon is not stated in the abstract.
Eligibility: 2 inclusion criteria; 1 exclusion criterion
Included
  • Children younger than 5 years
  • Women, for breast cancer deaths
Excluded
  • Not stated in the source that was read
  • Effect Evidence synthesis Certainty not assessed

    The authors estimate that scaling up breastfeeding to a near universal level could prevent 823,000 annual deaths in children younger than 5 years and 20,000 annual deaths from breast cancer.

    Applies to Mixed recipients
    • Annual deaths in children younger than 5 years and annual deaths from breast cancer in women, estimated by the review's model for a scale-up of breastfeeding to a near universal level. The estimate is a projection, not an observed trial result.
    • Not applicable (population-level estimate).
    • Not stated in the abstract for the estimate (the sentence refers to annual deaths without naming a region)
    • Children younger than 5 years, and women
    • Gestational age Not reported
    • Postnatal age Not reported
    Follow-up Annual estimate; the horizon is not stated in the abstract.
    Certainty method
    Not assessed
    Limitations
    Only the PubMed abstract of this review and meta-analysis was read; the full text was not. The abstract gives pooled conclusions without effect sizes. This is a modelled projection, not an observed trial result; the abstract does not give the assumptions behind it or say which countries it covers.
    Last checked
    2026-10-15
    Next evidence check due
    Not scheduled
    Sources and citations (2)
    1. Supports Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

      Publication · Lancet (London, England) · Edition PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched. · Published 2016-01-30 · DOI: 10.1016/S0140-6736(15)01024-7 · PMID: 26869575

      Locator
      Abstract, sentence 7, fragment 1 of 2
      How it applies
      PubMed abstract.
      Retrieved
      Source effective date
      Not reported
      Source state
      Current
      Snapshot hash
      880a968d1507804e2ba391e739f28569c97d4def79958233e4b1be5757a7ab92
      Reuse basis
      PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.
    2. Supports Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

      Publication · Lancet (London, England) · Edition PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched. · Published 2016-01-30 · DOI: 10.1016/S0140-6736(15)01024-7 · PMID: 26869575

      Locator
      Abstract, sentence 7, fragment 2 of 2
      How it applies
      PubMed abstract.
      Retrieved
      Source effective date
      Not reported
      Source state
      Current
      Snapshot hash
      880a968d1507804e2ba391e739f28569c97d4def79958233e4b1be5757a7ab92
      Reuse basis
      PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.

Context Women who breastfed or breastfed longer, in the studies pooled by the 2016 Lancet review

Recipient
Maternal
Population
Nursing women in the studies pooled by the review.
Care setting
Not stated in the abstract (the review pools studies from many settings).
Geography
Many countries (the abstract does not name them)
Life stage
Postpartum and later adult life
Gestational age
Not reported
Postnatal age
Not reported
Follow-up
Not stated in the abstract.
Eligibility: 1 inclusion criterion; 1 exclusion criterion
Included
  • Women who breastfed
Excluded
  • Not stated in the source that was read
  • Effect Evidence synthesis Certainty not assessed

    For nursing women, the authors report that breastfeeding gave protection against breast cancer and improved birth spacing, and that it might also protect against ovarian cancer and type 2 diabetes.

    Applies to Maternal
    • Nursing women in the studies pooled by the review.
    • Not stated in the abstract (the review pools studies from many settings).
    • Many countries (the abstract does not name them)
    • Postpartum and later adult life
    • Gestational age Not reported
    • Postnatal age Not reported
    Follow-up Not stated in the abstract.
    Certainty method
    Not assessed
    Limitations
    Only the PubMed abstract of this review and meta-analysis was read; the full text was not. The abstract gives pooled conclusions without effect sizes. The words might also protect mark the ovarian cancer and type 2 diabetes findings as uncertain in the abstract. It gives no number for the size of any protection.
    Last checked
    2026-10-15
    Next evidence check due
    Not scheduled
    Sources and citations (2)
    1. Supports Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

      Publication · Lancet (London, England) · Edition PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched. · Published 2016-01-30 · DOI: 10.1016/S0140-6736(15)01024-7 · PMID: 26869575

      Locator
      Abstract, sentence 6, fragment 1 of 2
      How it applies
      PubMed abstract.
      Retrieved
      Source effective date
      Not reported
      Source state
      Current
      Snapshot hash
      880a968d1507804e2ba391e739f28569c97d4def79958233e4b1be5757a7ab92
      Reuse basis
      PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.
    2. Supports Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect

      Publication · Lancet (London, England) · Edition PubMed record (abstract and bibliographic data) from NCBI E-utilities. The full text and the version of record were not fetched. · Published 2016-01-30 · DOI: 10.1016/S0140-6736(15)01024-7 · PMID: 26869575

      Locator
      Abstract, sentence 6, fragment 2 of 2
      How it applies
      PubMed abstract.
      Retrieved
      Source effective date
      Not reported
      Source state
      Current
      Snapshot hash
      880a968d1507804e2ba391e739f28569c97d4def79958233e4b1be5757a7ab92
      Reuse basis
      PubMed record fetched through NCBI E-utilities. Only the hash of the bytes is kept, because publisher copyright may apply to the abstract (https://pubmed.ncbi.nlm.nih.gov/disclaimer/). Short factual quotations under 25 words, with the citation.

Record details

Record id
maternal:pub-lancet-2016-breastfeeding
Content hash
526539732bccd3ead7a7333bc285de40fc762fd96a0e901ac3df7fd92b4dabd5