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BEAM trial (antenatal magnesium sulfate and cerebral palsy)

A US trial that tested whether magnesium sulfate given to women at imminent risk of delivering between 24 and 31 weeks would lower the risk of death or moderate or severe cerebral palsy in their children. It did not lower the combined risk; cerebral palsy alone was less common with magnesium sulfate.

  • Study
  • In this atlas

Overview

Design
Multicentre, placebo-controlled, double-blind randomised trial of magnesium sulfate (6-g intravenous bolus then 2 g per hour) against matching placebo, given to women at imminent risk of delivery between 24 and 31 weeks of gestation. Registry: allocation randomised, masking triple, primary purpose prevention.
Phase
Phase 3
Enrolled
  • 2,136 participants (registry; ClinicalTrials.gov gives no unit) (enrolled count) (Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial), retrieved )
  • 2,241 women (randomized count) (A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy, retrieved )
Sponsor
Not recorded
Funder
Not recorded
Registry
Not reported
Started
(Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial), retrieved )
Primary completion
(actual) (Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial), retrieved )
Completion
(actual) (Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial), retrieved )
Countries
United States (Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial), retrieved )
Care setting
Not reported
Registry status
  • “COMPLETED” (U.S. National Library of Medicine (ClinicalTrials.gov), retrieved )

Technical summary

Registry NCT00014989 (phase 3, randomised, masking triple, status COMPLETED; the lead sponsor on the registry is The George Washington University Biostatistics Center) and the 2008 paper, whose collective author is the Maternal-Fetal Medicine Units Network (PubMed abstract only). The registry enrolment is 2136 (actual); the paper reports 2241 women randomised. The two counts are not reconciled here.

Arms

Findings

No findings are published for this study.

Record details

Record id
maternal:beam-trial
Content hash
0c1d6d74e250f856f1ab89bd3c66d0c67c83a313d83a4ecf4523269a3bc8be58