{
  "release_id": "c7fb95f1d15a7d13",
  "id": "maternal:beam-trial",
  "owner": "maternal",
  "kind": "study",
  "slug": "beam-trial",
  "name": "BEAM trial (antenatal magnesium sulfate and cerebral palsy)",
  "aliases": [],
  "atlases": [
    "maternal"
  ],
  "summary_plain": "A US trial that tested whether magnesium sulfate given to women at imminent risk of delivering between 24 and 31 weeks would lower the risk of death or moderate or severe cerebral palsy in their children. It did not lower the combined risk; cerebral palsy alone was less common with magnesium sulfate.",
  "summary_technical": "Registry NCT00014989 (phase 3, randomised, masking triple, status COMPLETED; the lead sponsor on the registry is The George Washington University Biostatistics Center) and the 2008 paper, whose collective author is the Maternal-Fetal Medicine Units Network (PubMed abstract only). The registry enrolment is 2136 (actual); the paper reports 2241 women randomised. The two counts are not reconciled here.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-15",
  "next_review_due": null,
  "identifiers": [],
  "navigation": {
    "maternal": {
      "life-stage": [
        "pregnancy",
        "infant-follow-up"
      ],
      "care-area": [
        "preterm-and-sick-newborn"
      ]
    }
  },
  "payload": {
    "design": "Multicentre, placebo-controlled, double-blind randomised trial of magnesium sulfate (6-g intravenous bolus then 2 g per hour) against matching placebo, given to women at imminent risk of delivery between 24 and 31 weeks of gestation. Registry: allocation randomised, masking triple, primary purpose prevention.",
    "drug_phase": "3",
    "registry_statuses": [
      {
        "status": "COMPLETED",
        "snapshot": "maternal:ctgov-nct00014989-2026-10-15"
      }
    ],
    "start_date": {
      "date": "1997-12",
      "type": null,
      "snapshot": "maternal:ctgov-nct00014989-2026-10-15"
    },
    "primary_completion_date": {
      "date": "2007-02",
      "type": "actual",
      "snapshot": "maternal:ctgov-nct00014989-2026-10-15"
    },
    "completion_date": {
      "date": "2007-06",
      "type": "actual",
      "snapshot": "maternal:ctgov-nct00014989-2026-10-15"
    },
    "results_first_posted": null,
    "countries": [
      {
        "code": "US",
        "snapshot": "maternal:ctgov-nct00014989-2026-10-15"
      }
    ],
    "care_setting": null,
    "stopped_early": null,
    "enrollment": [
      {
        "count": 2136,
        "basis": "enrolled",
        "unit": "participants (registry; ClinicalTrials.gov gives no unit)",
        "snapshot": "maternal:ctgov-nct00014989-2026-10-15"
      },
      {
        "count": 2241,
        "basis": "randomized",
        "unit": "women",
        "snapshot": "maternal:pubmed-18753646-2026-10-14"
      }
    ],
    "arms": [
      {
        "id": "maternal:beam-trial-arm-magnesium-sulfate",
        "label": "Magnesium sulfate",
        "intervention": "maternal:magnesium-sulfate-fetal-neuroprotection",
        "description": "Intravenous 6-g bolus followed by a constant infusion of 2 g per hour (abstract)."
      },
      {
        "id": "maternal:beam-trial-arm-placebo",
        "label": "Placebo",
        "intervention": null,
        "description": "Matching placebo (abstract)."
      }
    ],
    "findings": []
  },
  "content_digest": "0c1d6d74e250f856f1ab89bd3c66d0c67c83a313d83a4ecf4523269a3bc8be58",
  "review": {
    "content_digest": "0c1d6d74e250f856f1ab89bd3c66d0c67c83a313d83a4ecf4523269a3bc8be58",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "investigates",
        "label": "Tests magnesium sulfate before early preterm birth",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "maternal:magnesium-sulfate-fetal-neuroprotection",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "maternal:ctgov-nct00014989-2026-10-15",
          "locator": "protocolSection.armsInterventionsModule.interventions[0].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Tests the medicine magnesium sulfate",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "maternal:magnesium-sulfate",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "maternal:ctgov-nct00014989-2026-10-15",
          "locator": "protocolSection.armsInterventionsModule.interventions[0].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": []
  },
  "page_path": "studies/beam-trial/",
  "context_path": "api/v1/context/maternal--beam-trial.md"
}