{
  "release_id": "fc5a600ec7387e71",
  "id": "maternal:tranexamic-acid",
  "owner": "maternal",
  "kind": "drug",
  "slug": "tranexamic-acid",
  "name": "Tranexamic acid",
  "aliases": [],
  "atlases": [
    "maternal"
  ],
  "summary_plain": "Tranexamic acid is a medicine that reduces bleeding by blocking the breakdown of blood clots. This atlas meets it in two separate roles, kept on separate pages: to treat heavy bleeding after birth that has started, and to try to prevent bleeding after birth. The two uses have different evidence.",
  "summary_technical": "Drug, level substance. RxCUI 10691 (RxNav name tranexamic acid, term type IN) read 2026-10-14. Mechanism (WOMAN introduction): it inhibits the enzymatic breakdown of fibrinogen and fibrin by plasmin. Uses kept apart: treatment of postpartum haemorrhage (the WOMAN trial and 2025 global Recommendation 27, on the existing treatment record) and prevention (WOMAN-2 and 2025 global Recommendations 14 and 15, on the prevention record). WOMAN-2 and the NCT03475342 registry record name the drug as the trial intervention. No clinical claim sits on this page.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-14",
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "rxnorm",
      "value": "10691",
      "normalized_value": "10691",
      "match": "exact",
      "version": null,
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "maternal": {
      "life-stage": [
        "childbirth",
        "postpartum"
      ],
      "care-area": [
        "postpartum-recovery"
      ]
    }
  },
  "payload": {
    "level": "substance",
    "mechanism": "Inhibits the enzymatic breakdown of fibrinogen and fibrin by plasmin (WOMAN introduction)."
  },
  "content_digest": "ca917e3acdb0f72b21d66f5628ed02886b64dfbcc8cf5f571fe186574d0c1106",
  "review": {
    "content_digest": "ca917e3acdb0f72b21d66f5628ed02886b64dfbcc8cf5f571fe186574d0c1106",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "related_to",
        "label": "Substance used for prevention",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "maternal:tranexamic-acid-pph-prevention",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "related_to",
        "label": "Substance used for treatment (existing record)",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "maternal:tranexamic-acid-pph-treatment",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "part_of",
        "label": "Filed under this front",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "maternal:front-medicines-and-vaccines",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": true,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": [
      {
        "predicate": "investigates",
        "label": "Investigated in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "maternal:e-motive-trial",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "maternal:ctgov-nct04341662-2026-10-14",
          "locator": "protocolSection.armsInterventionsModule.interventions[0].description"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Investigated in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "maternal:woman-2-trial",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "maternal:ctgov-nct03475342-2026-10-14",
          "locator": "protocolSection.armsInterventionsModule.interventions[0]"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Investigated in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "maternal:woman-trial",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "maternal:ctgov-nct00872469-2026-10-11",
          "locator": "protocolSection.armsInterventionsModule.interventions[0].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ]
  },
  "page_path": "drugs/tranexamic-acid/",
  "context_path": "api/v1/context/maternal--tranexamic-acid.md"
}