{
  "release_id": "c7fb95f1d15a7d13",
  "id": "maternal:rsvpref-vaccine",
  "owner": "maternal",
  "kind": "drug",
  "slug": "rsvpref-vaccine",
  "name": "RSVpreF (bivalent RSV prefusion F protein vaccine)",
  "aliases": [
    "RSVpreF"
  ],
  "atlases": [
    "maternal"
  ],
  "summary_plain": "The vaccine substance in Abrysvo: stabilised RSV prefusion F proteins of the A and B types in one vaccine. It is the substance tested in the MATISSE trial.",
  "summary_technical": "A fixed combination of the RSV A and B stabilised prefusion F protein drug substances (US approval letter; MATISSE abstract: a bivalent RSV prefusion F protein-based vaccine). RxNorm precise-ingredient concepts for the A and B proteins are RXCUI 2642138 and 2642139, recorded as broad codes because each is one part of the combination; they were looked up in RxNav, not quoted. The product is Abrysvo.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-15",
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "rxnorm",
      "value": "2642138",
      "normalized_value": "2642138",
      "match": "broad",
      "version": null,
      "label": null,
      "from_source": false
    },
    {
      "scheme": "rxnorm",
      "value": "2642139",
      "normalized_value": "2642139",
      "match": "broad",
      "version": null,
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "maternal": {
      "life-stage": [
        "pregnancy",
        "infant-follow-up"
      ],
      "care-area": [
        "infant-health"
      ]
    }
  },
  "payload": {
    "level": "combination",
    "mechanism": "Bivalent vaccine based on stabilised RSV prefusion F proteins A and B (US approval letter and trial abstract); the sources read do not describe how it works."
  },
  "content_digest": "08ba54c44a90604df24d75368320f29d4d7079eb6a197d25a4df200d2a61b14b",
  "review": {
    "content_digest": "08ba54c44a90604df24d75368320f29d4d7079eb6a197d25a4df200d2a61b14b",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "part_of",
        "label": "Filed under this front",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "maternal:front-medicines-and-vaccines",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": true,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": [
      {
        "predicate": "contains",
        "label": "Contained in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "maternal:abrysvo",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "maternal:fda-abrysvo-approval-letter-125768-2026-10-15",
          "locator": "Page 1, MANUFACTURING LOCATIONS, sentence 3 (part)"
        },
        "primary": false,
        "role": "active",
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Investigated in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "maternal:matisse-trial",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "maternal:ctgov-nct04424316-2026-10-15",
          "locator": "protocolSection.armsInterventionsModule.interventions[0].name"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ]
  },
  "page_path": "drugs/rsvpref-vaccine/",
  "context_path": "api/v1/context/maternal--rsvpref-vaccine.md"
}