{
  "release_id": "fc5a600ec7387e71",
  "id": "maternal:retinopathy-of-prematurity",
  "owner": "maternal",
  "kind": "condition",
  "slug": "retinopathy-of-prematurity",
  "name": "Retinopathy of prematurity",
  "aliases": [
    "ROP"
  ],
  "atlases": [
    "maternal"
  ],
  "summary_plain": "An eye disease that can happen in babies born early or who weigh under about 3 pounds at birth. Abnormal blood vessels grow in the retina, the light-sensitive layer at the back of the eye. Some babies have mild disease that gets better without treatment; others need treatment to protect their sight. The National Eye Institute says there are no signs a parent can see, so babies at risk have a dilated eye exam a few weeks after birth.",
  "summary_technical": "Condition page, from the NEI patient page (public domain). NEI gives the risk as birth before 30 weeks of pregnancy or weight under about 3 pounds, and the first exam as usually between 4 and 9 weeks after birth. Treatments it lists: observation for mild disease, laser treatment, injections of anti-VEGF medicines and eye surgery. The two trial pages (ETROP and the aflibercept record) carry the evidence. A 2018 policy statement on screening examination of premature infants was published in the journal Pediatrics; it is listed as an identity-only reference and its content was not read, so no screening schedule or criteria are recorded here. No incidence figure is recorded.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-15",
  "next_review_due": null,
  "identifiers": [],
  "navigation": {
    "maternal": {
      "life-stage": [
        "newborn",
        "infant-follow-up"
      ],
      "care-area": [
        "preterm-and-sick-newborn"
      ]
    }
  },
  "payload": {
    "recognition": "NEI: there are no signs of ROP that a parent can see; at-risk babies are checked with a dilated eye exam.",
    "assessment": null,
    "burden_claims": []
  },
  "content_digest": "ecaeb2c00e05a1c269131644b5aa6ad81f932e7a7a12a301120f1b220bddc471",
  "review": {
    "content_digest": "ecaeb2c00e05a1c269131644b5aa6ad81f932e7a7a12a301120f1b220bddc471",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "related_to",
        "label": "Risk rises with earlier birth (existing page)",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "maternal:preterm-birth",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "part_of",
        "label": "Filed under this front",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "maternal:front-screening-and-tests",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": true,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": [
      {
        "predicate": "related_to",
        "label": "Related to",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "maternal:developmental-surveillance",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "evaluated_for",
        "label": "Evaluated for this",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "maternal:aflibercept",
        "other_entity_in_atlas": true,
        "claim_id": "maternal:claim-aflibercept-fireflye-rop",
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "treats",
        "label": "Treated by",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "maternal:eylea-rop",
        "other_entity_in_atlas": true,
        "claim_id": "maternal:claim-eylea-label-rop-indication",
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "investigates",
        "label": "Investigated in",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "maternal:etrop-trial",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "maternal:ctgov-nct00027222-2026-10-15",
          "locator": "protocolSection.conditionsModule.conditions[0]"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ]
  },
  "page_path": "conditions/retinopathy-of-prematurity/",
  "context_path": "api/v1/context/maternal--retinopathy-of-prematurity.md"
}