{
  "release_id": "fc5a600ec7387e71",
  "id": "maternal:pop-ht-trial",
  "owner": "maternal",
  "kind": "study",
  "slug": "pop-ht-trial",
  "name": "POP-HT trial (Physician Optimised Post-partum Hypertension Treatment)",
  "aliases": [
    "POP-HT"
  ],
  "atlases": [
    "maternal"
  ],
  "summary_plain": "A UK trial in women who had high blood pressure in pregnancy and still needed blood pressure medicine when they left hospital. Half used a home blood pressure monitor and a phone app, with doctors approving changes to their medicine; half had usual postnatal care. The women who self-monitored had lower blood pressure about 9 months after birth.",
  "summary_technical": "Randomised, parallel-group trial (NCT04273854; phase not applicable). The paper (JAMA 2023, PMID 37950919) reports 220 randomised (112 intervention, 108 control) at a single UK hospital, with first enrolment on 21 February 2020 and last follow-up on 2 November 2021 (abstract); the primary outcome was the 24-hour mean diastolic pressure at 9 months after birth, adjusted for baseline. The registry (last update posted 2021-10-22) lists 200 as the estimated enrolment, ACTIVE_NOT_RECRUITING, estimated primary completion 2022-04-01 and estimated completion 2030-12-01, a primary outcome time frame of 6 months, and single masking of the outcomes assessor. The registry and the paper are not reconciled here. Registry lead sponsor: University of Oxford, with the British Heart Foundation as collaborator; neither is an organisation record in this atlas, so no sponsor link is made. Only the PubMed abstract was read.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-15",
  "last_evidence_check": "2026-10-15",
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "nct",
      "value": "NCT04273854",
      "normalized_value": "NCT04273854",
      "match": "exact",
      "version": null,
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "maternal": {
      "life-stage": [
        "postpartum"
      ],
      "care-area": [
        "postpartum-recovery"
      ]
    }
  },
  "payload": {
    "design": "Allocation: randomised. Intervention model: parallel. Masking: single (outcomes assessor, registry); the paper calls it open-label with a blinded end point. Primary purpose: prevention (registry values, paraphrased).",
    "drug_phase": "not_applicable",
    "registry_statuses": [
      {
        "status": "ACTIVE_NOT_RECRUITING",
        "snapshot": "maternal:ctgov-nct04273854-2026-10-15"
      }
    ],
    "start_date": {
      "date": "2020-02-21",
      "type": "actual",
      "snapshot": "maternal:ctgov-nct04273854-2026-10-15"
    },
    "primary_completion_date": {
      "date": "2022-04-01",
      "type": "anticipated",
      "snapshot": "maternal:ctgov-nct04273854-2026-10-15"
    },
    "completion_date": {
      "date": "2030-12-01",
      "type": "anticipated",
      "snapshot": "maternal:ctgov-nct04273854-2026-10-15"
    },
    "results_first_posted": null,
    "countries": [
      {
        "code": "GB",
        "snapshot": "maternal:ctgov-nct04273854-2026-10-15"
      }
    ],
    "care_setting": {
      "description": "A single hospital in the UK (the abstract). The registry lists two sites, both in Oxford.",
      "snapshot": "maternal:pubmed-37950919-2026-10-15"
    },
    "stopped_early": null,
    "enrollment": [
      {
        "count": 200,
        "basis": "planned",
        "unit": "participants (registry enrolment, type ESTIMATED)",
        "snapshot": "maternal:ctgov-nct04273854-2026-10-15"
      },
      {
        "count": 112,
        "basis": "randomized",
        "unit": "participants assigned to the intervention group",
        "snapshot": "maternal:pubmed-37950919-2026-10-15"
      },
      {
        "count": 108,
        "basis": "randomized",
        "unit": "participants assigned to the control group",
        "snapshot": "maternal:pubmed-37950919-2026-10-15"
      }
    ],
    "arms": [
      {
        "id": "maternal:pop-ht-trial-arm-intervention",
        "label": "Self-monitoring with physician-guided medicine changes",
        "intervention": "maternal:postpartum-bp-self-management",
        "description": "Women monitored their own blood pressure and followed a smartphone app algorithm that advised changes in medicine dose, overseen and approved by physicians (registry arm and intervention descriptions, paraphrased)."
      },
      {
        "id": "maternal:pop-ht-trial-arm-control",
        "label": "Usual postnatal care",
        "intervention": null,
        "description": "Usual NHS-led care, with the women's own health professionals assessing them and adjusting their medicine as needed; blood pressure was recorded at the same time points as in the intervention arm (registry arm description, paraphrased)."
      }
    ],
    "findings": []
  },
  "content_digest": "5ba764c98cf5d8a8e5ebb789e16151ea11344da8ce96bea06a2c98bed406616b",
  "review": {
    "content_digest": "5ba764c98cf5d8a8e5ebb789e16151ea11344da8ce96bea06a2c98bed406616b",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "investigates",
        "label": "Tests self-monitoring with doctor-guided medicine changes against usual care",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "maternal:postpartum-bp-self-management",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "maternal:ctgov-nct04273854-2026-10-15",
          "locator": "protocolSection.armsInterventionsModule.armGroups[0].description"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": []
  },
  "page_path": "studies/pop-ht-trial/",
  "context_path": "api/v1/context/maternal--pop-ht-trial.md"
}