{ "release_id": "15708f235d73cd42", "id": "maternal:nulliparity", "owner": "maternal", "kind": "risk_factor", "slug": "nulliparity", "name": "Nulliparity", "aliases": [], "atlases": [ "maternal" ], "summary_plain": "NICE uses the term nulliparity without defining it. MeSH files it under parity, which MeSH defines as \"The number of offspring a female has borne.\" NICE lists it as one of six moderate risk factors for pre-eclampsia. Having more than one of these factors is a reason NICE gives for advising low-dose aspirin. NICE does not say how much nulliparity raises the risk by itself.", "summary_technical": "A trait of the pregnant woman. The NICE NG133 page does not define nulliparity. In August 2022 NICE changed the wording of recommendation 1.1.3 from first pregnancy to nulliparity, so the two terms must not be treated as the same. MeSH defines parity as the number of offspring a female has borne, and files nulliparity under it with no definition of its own. WHO 2021 uses a different term, primiparity, in its own moderate-risk list, and this record does not treat primiparity and nulliparity as the same.", "editorial_state": "draft", "last_substantive_edit": "2026-10-12", "last_evidence_check": "2026-10-12", "next_review_due": null, "external_ids": [], "navigation": { "maternal": { "life-stage": [ "pregnancy" ] } }, "payload": { "factor_type": "trait", "definition": "MeSH defines parity as \"The number of offspring a female has borne.\" and lists nulliparity as a narrower concept of parity without a definition of its own. NICE gives no definition.", "contexts": [ "maternal:ctx-nice-ng133-nulliparity-moderate-risk" ] }, "content_digest": "a508fe3aea2fd347e181c525e3b9c169d612509e9165023988c02a4e82758f2d", "review": { "content_digest": "a508fe3aea2fd347e181c525e3b9c169d612509e9165023988c02a4e82758f2d", "current": [], "conflicting": [], "stale": [], "inactive": [] }, "claims": [ { "release_id": "15708f235d73cd42", "id": "maternal:claim-nice-ng133-1-1-3-nulliparity-risk-factor", "owner": "maternal", "subject_entity_id": "maternal:nulliparity", "category": "descriptive", "statement": "NICE lists nulliparity as one of six factors that indicate moderate risk of pre-eclampsia, alongside age 40 years or older, a pregnancy interval of more than 10 years, a body mass index of 35 kg/m2 or more at the first visit, a family history of pre-eclampsia and a multi-fetal pregnancy. NICE advises aspirin for women who have more than one of these factors.", "context": { "id": "maternal:ctx-nice-ng133-nulliparity-moderate-risk", "label": "Nulliparity as one moderate risk factor for pre-eclampsia (NICE NG133 recommendation 1.1.3)", "recipient": "maternal", "population": "Pregnant women with nulliparity, one of six factors that NICE lists as indicating moderate risk of pre-eclampsia. The NICE page does not define nulliparity.", "care_setting": "Not stated in the source.", "geography": "England. NICE's terms and conditions present the information on its websites as support for people in England who make decisions about funding care (clause 6) and say it is not written as a basis for decisions outside the United Kingdom (clause 8). The guideline page states no jurisdiction of its own.", "life_stage": "Pregnancy. The source gives no gestational age for the risk factor itself.", "gestational_age_min_days": null, "gestational_age_max_days": null, "postnatal_age_min_days": null, "postnatal_age_max_days": null, "gestational_age_status": null, "postnatal_age_status": null, "followup_description": "Not applicable (risk factor context)", "eligibility": { "inclusion": [ "Pregnant woman with nulliparity" ], "exclusion": [ "Not stated in the recommendation text" ] } }, "evidence_stage": "guidance", "certainty": "not_assessed", "certainty_method": null, "limitations": "NICE does not say how much nulliparity raises the risk by itself, and the NICE page does not define the term, so no risk figure is recorded. In August 2022 NICE corrected the wording of recommendation 1.1.3 from first pregnancy to nulliparity, so the two terms must not be used as if they meant the same. WHO 2021 uses a different term, primiparity, in its own moderate-risk list. A list of risk factors is not an estimate of risk for any one woman.", "editorial_state": "draft", "checked_at": "2026-10-11", "next_review_due": null, "valid_from": null, "valid_to": null, "citations": [ { "evidence_role": "supports", "locator": "1.1.3, moderate-risk list, items 1 to 3", "applicability_note": "NICE NG133, cited and linked only. 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