{ "release_id": "fc5a600ec7387e71", "id": "maternal:neonatal-eos-calculator", "owner": "maternal", "kind": "resource", "slug": "neonatal-eos-calculator", "name": "Neonatal early-onset sepsis calculator", "aliases": [], "atlases": [ "maternal" ], "summary_plain": "A risk tool for newborns born at 35 weeks or later. It combines objective information available at birth with the baby's clinical condition to estimate the risk of early-onset sepsis, so that fewer well babies have blood tests and antibiotics. In one large US health system, its use went with less blood culture testing and less early antibiotic use, and no sign of harm in the 2017 report.", "summary_technical": "Resource, tool. The 2017 paper (PubMed abstract) describes multivariable prediction models for estimating the risk of early-onset sepsis among late preterm and term infants from objective data at birth and the newborn's clinical status, and reports their use in a before-and-after comparison; it is not a randomised trial. A 2024 update was published in Pediatrics; it is an identity-only reference and its content was not read. No model coefficients, thresholds or recommended actions are recorded here.", "editorial_state": "draft", "last_substantive_edit": "2026-10-15", "last_evidence_check": "2026-10-15", "next_review_due": null, "identifiers": [], "navigation": { "maternal": { "life-stage": [ "newborn" ], "care-area": [ "preterm-and-sick-newborn" ] } }, "payload": { "resource_type": "tool", "owner": null, "contents": "Multivariable models that estimate the risk of early-onset sepsis in infants born at 35 weeks or later from objective data at birth and the infant's clinical condition (JAMA Pediatrics 2017 abstract).", "access": "Not stated in the sources read.", "license": null }, "content_digest": "e60a8bb29f20fc50be05f7e41b9d581a42c73c75366d2169ffacd0905808cfc5", "review": { "content_digest": "e60a8bb29f20fc50be05f7e41b9d581a42c73c75366d2169ffacd0905808cfc5", "current": [], "conflicting": [], "stale": [], "inactive": [] }, "claims": [ { "release_id": "fc5a600ec7387e71", "id": "maternal:claim-eos-calculator-kpnc", "owner": "maternal", "subject_entity_id": "maternal:neonatal-eos-calculator", "category": "effect", "statement": "In a cohort of 204,485 infants born at 35 weeks or later at Kaiser Permanente Northern California hospitals from 2010 to 2015, care guided by a multivariable early-onset sepsis risk estimate combined with the infant's clinical condition in the first 24 hours (the EOS calculator period) was compared with an earlier baseline period that followed national recommended guidelines. Blood culture use fell from 14.5% to 4.9% (adjusted difference -7.7%; 95% CI -13.1% to -2.4%) and empirical antibiotic use in the first 24 hours fell from 5.0% to 2.6% (adjusted difference -1.8; 95% CI -2.4% to -1.3%). Antibiotic use between 24 and 72 hours did not increase (0.5% to 0.4%). Culture-confirmed early-onset sepsis was 0.03% in the baseline period, 0.03% in the learning period and 0.02% in the calculator period. Readmissions for early-onset sepsis within 7 days did not differ statistically (P = .70), and adverse clinical outcomes, including inotrope use, mechanical ventilation, meningitis and death, were unchanged. The authors conclude that the algorithms reduced testing and empirical antibiotics without apparent adverse effects.", "context": { "id": "maternal:ctx-eos-calculator-infants-35w", "label": "Infants born at 35 weeks or later in a Kaiser Permanente Northern California cohort (early-onset sepsis risk models)", "recipient": "newborn", "population": "204,485 infants born at 35 weeks' gestation or later at Kaiser Permanente Northern California hospitals between January 1, 2010, and December 31, 2015. The models estimate sepsis risk among late preterm and term infants from objective data available at birth and the newborn's clinical status. The abstract does not apply them to infants born before 35 weeks.", "care_setting": "Hospitals of one integrated health care system (Kaiser Permanente Northern California)", "geography": "United States (Northern California)", "life_stage_note": "Late preterm and term newborns, in the first 24 hours after birth for the calculator period", "life_stage_terms": { "maternal": [ "newborn" ] }, "gestational_age_min_days": null, "gestational_age_max_days": null, "gestational_age_basis": null, "postnatal_age_min_days": null, "postnatal_age_max_days": null, "gestational_age_status": null, "postnatal_age_status": null, "followup_description": "Antibiotic administration in the first 24 hours (primary outcome); blood culture use, antibiotics from 24 to 72 hours, clinical outcomes and readmissions for early-onset sepsis (secondary).", "eligibility": { "inclusion": [ "Infants born at 35 weeks' gestation or later" ], "exclusion": [] } }, "evidence_stage": "observational", "certainty": "not_assessed", "certainty_method": null, "limitations": "Only the abstract was read. It compares successive periods in one health system, not randomised groups, so other changes over time could contribute. It covers infants born at 35 weeks or later only. A 2024 update to the calculator was published in the journal Pediatrics; that article is an identity-only source in this atlas, so nothing from it is recorded and the figures here are those of the 2017 paper.", "editorial_state": "draft", "checked_at": "2026-10-15", "next_review_due": null, "valid_from": null, "valid_to": null, "citations": [ { "evidence_role": "supports", "locator": "Abstract, RESULTS sentences 2 to 7 and CONCLUSIONS AND RELEVANCE", "applicability_note": "Testing, antibiotic use, incidence, readmissions and clinical outcomes.", "snapshot": { "id": "maternal:pubmed-28241253-2026-10-15", "retrieved_at": "2026-10-15T13:49:25Z", "content_hash": "32f5da887042769e27a99cb2701ee7d62ad2ad500f61142507f6c098c89acc4e", "source_effective_date": null, "public_archive_url": null, "source_state": "current" }, "source": { "id": "maternal:pubmed-10-1001-jamapediatrics-2016-4678", "source_type": "publication", "title": "A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis", "canonical_url": "https://doi.org/10.1001/jamapediatrics.2016.4678", "identifiers": [ { "scheme": "doi", "value": "10.1001/jamapediatrics.2016.4678", "normalized_value": "10.1001/jamapediatrics.2016.4678", "match": "exact", "version": null, "label": null, "from_source": false }, { "scheme": "pmid", "value": "28241253", "normalized_value": "28241253", "match": "exact", "version": null, "label": null, "from_source": false } ], "publication_date": "2017-04-01", "publisher": "JAMA pediatrics", "edition": "PubMed record (abstract and bibliographic data) from NCBI E-utilities. 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