{
  "release_id": "c7fb95f1d15a7d13",
  "id": "maternal:hypoxic-ischaemic-encephalopathy",
  "owner": "maternal",
  "kind": "condition",
  "slug": "hypoxic-ischaemic-encephalopathy",
  "name": "Brain injury from lack of oxygen around birth (HIE)",
  "aliases": [
    "Hypoxic-ischemic encephalopathy",
    "HIE",
    "Neonatal encephalopathy"
  ],
  "atlases": [
    "maternal"
  ],
  "summary_plain": "Brain injury in a newborn after a period of low oxygen around birth. Babies with moderate or severe HIE are the babies in the cooling trials recorded here.",
  "summary_technical": "Studied with whole-body cooling in two trials whose results differ by setting: a trial in US neonatal units (published 2005) and HELIX in India, Sri Lanka and Bangladesh (published 2021). This record gives no clinical definition; the entry criteria of each trial are in the context records for its claims.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-14",
  "last_evidence_check": null,
  "next_review_due": null,
  "identifiers": [],
  "navigation": {
    "maternal": {
      "life-stage": [
        "newborn"
      ],
      "care-area": [
        "newborn-care"
      ]
    }
  },
  "payload": {
    "recognition": "Not defined here. Each trial's entry criteria are in its context record.",
    "assessment": null,
    "burden_claims": []
  },
  "content_digest": "92c37466d5ac8bad29424284899945f9a3843a1d9f64558ba8b6b5220a0e1b88",
  "review": {
    "content_digest": "92c37466d5ac8bad29424284899945f9a3843a1d9f64558ba8b6b5220a0e1b88",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "related_to",
        "label": "Related page: birth asphyxia and resuscitation",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "maternal:neonatal-resuscitation",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "part_of",
        "label": "Filed under this front",
        "clinical_claim_not_fact": false,
        "family": "navigation",
        "other_entity_id": "maternal:front-newborn-support",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": null,
        "primary": true,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": [
      {
        "predicate": "treats",
        "label": "Treated by",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "maternal:therapeutic-hypothermia",
        "other_entity_in_atlas": true,
        "claim_id": "maternal:claim-nichd-cooling-death-or-disability",
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "evaluated_for",
        "label": "Evaluated for this",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "maternal:therapeutic-hypothermia",
        "other_entity_in_atlas": true,
        "claim_id": "maternal:claim-helix-death-or-disability",
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      },
      {
        "predicate": "evaluated_for",
        "label": "Evaluated for this",
        "clinical_claim_not_fact": true,
        "family": "clinical",
        "other_entity_id": "maternal:therapeutic-hypothermia",
        "other_entity_in_atlas": true,
        "claim_id": "maternal:claim-helix-death",
        "evidence": null,
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ]
  },
  "page_path": "conditions/hypoxic-ischaemic-encephalopathy/",
  "context_path": "api/v1/context/maternal--hypoxic-ischaemic-encephalopathy.md"
}