{
  "release_id": "c7fb95f1d15a7d13",
  "id": "maternal:apts-trial",
  "owner": "maternal",
  "kind": "study",
  "slug": "apts-trial",
  "name": "Australian Placental Transfusion Study (APTS)",
  "aliases": [],
  "atlases": [
    "maternal"
  ],
  "summary_plain": "A large trial that compared waiting at least 60 seconds with clamping the cord within 10 seconds in babies expected to be born before 30 weeks.",
  "summary_technical": "Multicentre randomised trial reported in 2017. The registry number printed in the abstract is ACTRN12610000633088 (ANZCTR); the registry record was not fetched. 1634 fetuses were randomised and 1566 were born alive before 30 weeks (782 immediate clamping, 784 delayed clamping). Primary composite outcome: death or major morbidity by 36 weeks of postmenstrual age. The abstract names the Australian National Health and Medical Research Council and the NHMRC Clinical Trials Centre as funders.",
  "editorial_state": "draft",
  "last_substantive_edit": "2026-10-14",
  "last_evidence_check": null,
  "next_review_due": null,
  "identifiers": [
    {
      "scheme": "anzctr",
      "value": "ACTRN12610000633088",
      "normalized_value": "ACTRN12610000633088",
      "match": "exact",
      "version": null,
      "label": null,
      "from_source": false
    }
  ],
  "navigation": {
    "maternal": {
      "life-stage": [
        "childbirth",
        "newborn"
      ],
      "care-area": [
        "preterm-and-sick-newborn"
      ]
    }
  },
  "payload": {
    "design": "Randomised trial in which fetuses of women expected to deliver before 30 weeks of gestation were assigned to immediate cord clamping (10 seconds or less after delivery) or delayed clamping (60 seconds or more after delivery). Intention-to-treat analysis accounting for multiple births.",
    "drug_phase": null,
    "registry_statuses": [],
    "start_date": null,
    "primary_completion_date": null,
    "completion_date": null,
    "results_first_posted": null,
    "countries": [
      {
        "code": "AU",
        "snapshot": "maternal:apts-anzctr-2026-10-14"
      },
      {
        "code": "NZ",
        "snapshot": "maternal:apts-anzctr-2026-10-14"
      },
      {
        "code": "GB",
        "snapshot": "maternal:apts-anzctr-2026-10-14"
      },
      {
        "code": "PK",
        "snapshot": "maternal:apts-anzctr-2026-10-14"
      },
      {
        "code": "FR",
        "snapshot": "maternal:apts-anzctr-2026-10-14"
      },
      {
        "code": "US",
        "snapshot": "maternal:apts-anzctr-2026-10-14"
      },
      {
        "code": "CA",
        "snapshot": "maternal:apts-anzctr-2026-10-14"
      }
    ],
    "care_setting": null,
    "stopped_early": null,
    "enrollment": [
      {
        "count": 1634,
        "basis": "randomized",
        "unit": "fetuses (women expected to deliver before 30 weeks)",
        "snapshot": "maternal:pubmed-29081267-2026-10-14"
      }
    ],
    "arms": [
      {
        "id": "maternal:apts-trial-arm-immediate",
        "label": "Immediate cord clamping",
        "intervention": "maternal:delayed-cord-clamping",
        "description": "Cord clamped 10 seconds or less after delivery. The median time to clamping was 5 seconds."
      },
      {
        "id": "maternal:apts-trial-arm-delayed",
        "label": "Delayed cord clamping",
        "intervention": "maternal:delayed-cord-clamping",
        "description": "Cord clamped 60 seconds or more after delivery. The median time to clamping was 60 seconds."
      }
    ],
    "findings": []
  },
  "content_digest": "4cb6ddd6fb38c1aa995c19046efe44cf529ea89ed18b34864f80f3b2af73c52e",
  "review": {
    "content_digest": "4cb6ddd6fb38c1aa995c19046efe44cf529ea89ed18b34864f80f3b2af73c52e",
    "current": [],
    "conflicting": [],
    "stale": [],
    "inactive": []
  },
  "claims": [],
  "decisions": [],
  "milestones": [],
  "relationships": {
    "outgoing": [
      {
        "predicate": "investigates",
        "label": "Compares delayed with immediate clamping",
        "clinical_claim_not_fact": false,
        "family": "sourced",
        "other_entity_id": "maternal:delayed-cord-clamping",
        "other_entity_in_atlas": true,
        "claim_id": null,
        "evidence": {
          "snapshot_id": "maternal:pubmed-29081267-2026-10-14",
          "locator": "Abstract, METHODS, sentence 1"
        },
        "primary": false,
        "role": null,
        "valid_from": null,
        "valid_to": null
      }
    ],
    "incoming": []
  },
  "page_path": "studies/apts-trial/",
  "context_path": "api/v1/context/maternal--apts-trial.md"
}