# POP-HT trial (Physician Optimised Post-partum Hypertension Treatment)

Study · id `maternal:pop-ht-trial` · Maternal & Newborn Atlas · release `c7fb95f1d15a7d13` (public)

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Also called: POP-HT

Browse, life stage: Postpartum  
Browse, care area: Recovery after birth  

## In plain language

A UK trial in women who had high blood pressure in pregnancy and still needed blood pressure medicine when they left hospital. Half used a home blood pressure monitor and a phone app, with doctors approving changes to their medicine; half had usual postnatal care. The women who self-monitored had lower blood pressure about 9 months after birth.

## Technical summary

Randomised, parallel-group trial (NCT04273854; phase not applicable). The paper (JAMA 2023, PMID 37950919) reports 220 randomised (112 intervention, 108 control) at a single UK hospital, with first enrolment on 21 February 2020 and last follow-up on 2 November 2021 (abstract); the primary outcome was the 24-hour mean diastolic pressure at 9 months after birth, adjusted for baseline. The registry (last update posted 2021-10-22) lists 200 as the estimated enrolment, ACTIVE\_NOT\_RECRUITING, estimated primary completion 2022-04-01 and estimated completion 2030-12-01, a primary outcome time frame of 6 months, and single masking of the outcomes assessor. The registry and the paper are not reconciled here. Registry lead sponsor: University of Oxford, with the British Heart Foundation as collaborator; neither is an organisation record in this atlas, so no sponsor link is made. Only the PubMed abstract was read.

## Key facts

- Design: Allocation: randomised. Intervention model: parallel. Masking: single (outcomes assessor, registry); the paper calls it open-label with a blinded end point. Primary purpose: prevention (registry values, paraphrased).
- Phase: Not applicable
- Enrolled: 200 participants (registry enrolment, type ESTIMATED) (planned count; Physician Optimised Post-partum Hypertension Treatment Trial, snapshot `maternal:ctgov-nct04273854-2026-10-15`, retrieved 2026-10-15); 112 participants assigned to the intervention group (randomized count; Long-Term Blood Pressure Control After Hypertensive Pregnancy Following Physician-Optimized Self-Management: The POP-HT Randomized Clinical Trial, snapshot `maternal:pubmed-37950919-2026-10-15`, retrieved 2026-10-15); 108 participants assigned to the control group (randomized count; Long-Term Blood Pressure Control After Hypertensive Pregnancy Following Physician-Optimized Self-Management: The POP-HT Randomized Clinical Trial, snapshot `maternal:pubmed-37950919-2026-10-15`, retrieved 2026-10-15)
- Started: 2020-02-21 (actual) (Physician Optimised Post-partum Hypertension Treatment Trial, snapshot `maternal:ctgov-nct04273854-2026-10-15`, retrieved 2026-10-15)
- Primary completion: 2022-04-01 (anticipated) (Physician Optimised Post-partum Hypertension Treatment Trial, snapshot `maternal:ctgov-nct04273854-2026-10-15`, retrieved 2026-10-15)
- Completion: 2030-12-01 (anticipated) (Physician Optimised Post-partum Hypertension Treatment Trial, snapshot `maternal:ctgov-nct04273854-2026-10-15`, retrieved 2026-10-15)
- Countries: United Kingdom (Physician Optimised Post-partum Hypertension Treatment Trial, snapshot `maternal:ctgov-nct04273854-2026-10-15`, retrieved 2026-10-15)
- Care setting: A single hospital in the UK (the abstract). The registry lists two sites, both in Oxford. (Long-Term Blood Pressure Control After Hypertensive Pregnancy Following Physician-Optimized Self-Management: The POP-HT Randomized Clinical Trial, snapshot `maternal:pubmed-37950919-2026-10-15`, retrieved 2026-10-15)
- Registry status: "ACTIVE\_NOT\_RECRUITING" (U.S. National Library of Medicine (ClinicalTrials.gov), snapshot `maternal:ctgov-nct04273854-2026-10-15`, retrieved 2026-10-15)

## Connected pages

- Tests self-monitoring with doctor-guided medicine changes against usual care: Blood pressure self-monitoring and physician-guided dose changes after birth (`maternal:postpartum-bp-self-management`)

## Provenance

Content hash: 5ba764c98cf5d8a8e5ebb789e16151ea11344da8ce96bea06a2c98bed406616b
Last substantive edit: 2026-10-15
Evidence last checked: 2026-10-15