# Brain injury from lack of oxygen around birth (HIE)

Condition · id `maternal:hypoxic-ischaemic-encephalopathy` · Maternal & Newborn Atlas · release `c7fb95f1d15a7d13` (public)

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Also called: Hypoxic-ischemic encephalopathy; HIE; Neonatal encephalopathy

Browse, life stage: Newborn  
Browse, care area: Newborn care  

## In plain language

Brain injury in a newborn after a period of low oxygen around birth. Babies with moderate or severe HIE are the babies in the cooling trials recorded here.

## Technical summary

Studied with whole-body cooling in two trials whose results differ by setting: a trial in US neonatal units (published 2005) and HELIX in India, Sri Lanka and Bangladesh (published 2021). This record gives no clinical definition; the entry criteria of each trial are in the context records for its claims.

## Connected pages

- Related page: birth asphyxia and resuscitation: Newborn resuscitation (help with breathing at birth) (`maternal:neonatal-resuscitation`)
- Filed under this front: Newborn support: warmth, breathing, feeding (`maternal:front-newborn-support`)
- Treated by: Cooling treatment (therapeutic hypothermia) for HIE (`maternal:therapeutic-hypothermia`) [a claim, not a settled fact; see claim `maternal:claim-nichd-cooling-death-or-disability` and its context]
- Evaluated for this: Cooling treatment (therapeutic hypothermia) for HIE (`maternal:therapeutic-hypothermia`) [a claim, not a settled fact; see claim `maternal:claim-helix-death-or-disability` and its context]
- Evaluated for this: Cooling treatment (therapeutic hypothermia) for HIE (`maternal:therapeutic-hypothermia`) [a claim, not a settled fact; see claim `maternal:claim-helix-death` and its context]

## Provenance

Content hash: 92c37466d5ac8bad29424284899945f9a3843a1d9f64558ba8b6b5220a0e1b88
Last substantive edit: 2026-10-14
Evidence last checked: Not recorded